Design of self-dispersible dry nanosuspension through wet milling and spray freeze-drying for poorly water-soluble drugs
T Niwa, K Danjo - European Journal of Pharmaceutical Sciences, 2013 - Elsevier
… technique starting from wet nano-milling, named “dry nanosuspension” technique for
poorly water-soluble drugs. The spray freeze-drying (SFD) method was applied instead of the …
poorly water-soluble drugs. The spray freeze-drying (SFD) method was applied instead of the …
Design of self-dispersible microsponge containing cyclosporine through wet milling and drop freeze-drying processes to improve dissolution behavior
M Kobayashi, K Kondo, C Nakashima, Y Kida… - Journal of Drug Delivery …, 2020 - Elsevier
… spray freeze-drying (SFD) method combined with wet-milling … the milled nanosuspension
dropwise from a nozzle tip into liquid … tool improving the solubility of poorly water-soluble drugs. …
dropwise from a nozzle tip into liquid … tool improving the solubility of poorly water-soluble drugs. …
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders
M Malamatari, S Somavarapu, KMG Taylor… - … opinion on drug …, 2016 - Taylor & Francis
… spray-freeze drying of drug nanosuspensions was suggested as a novel dissolution-enhancing
technique for poorly water-soluble drugs… of the concept of quality by design [Citation96]. …
technique for poorly water-soluble drugs… of the concept of quality by design [Citation96]. …
Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges
… of drug nanocrystals, with an emphasis on wet milling, while … Freeze drying of drug
nanosuspensions prepared via LASP … nanocomposite particles by freeze drying and spray drying. …
nanosuspensions prepared via LASP … nanocomposite particles by freeze drying and spray drying. …
… : Physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® nanocrystals formulated through wet milling and freeze-drying
A Rossetti, DA Real, BA Barrientos… - International Journal of …, 2024 - Elsevier
… with Tween 80® were designed by wet milling. A full factorial … with different cryoprotectants
was carried out to obtain a dry … the nanocrystals as a nanosuspension and would be slowed …
was carried out to obtain a dry … the nanocrystals as a nanosuspension and would be slowed …
Active freeze drying for production of nanocrystal-based powder: a pilot study
A Touzet, F Pfefferlé, P van der Wel… - International journal of …, 2018 - Elsevier
… using ketoconazole as a poorly water-soluble model drug. By the means of a design of …
is only caused by the freeze-drying phase as the nanosuspensions were physically stable …
is only caused by the freeze-drying phase as the nanosuspensions were physically stable …
Solidification of hesperidin nanosuspension by spray drying optimized by design of experiment (DoE)
Q Wei, CM Keck, RH Müller - Drug development and industrial …, 2018 - Taylor & Francis
… original and redispersed spray-dried nanosuspensions were … improve the solubility of poorly
water-soluble drugs [Citation1,… drying or freeze drying [Citation7–10]. The obtained products …
water-soluble drugs [Citation1,… drying or freeze drying [Citation7–10]. The obtained products …
Design of xerogel pill with good swallowing performance through wet milling and drop freeze-drying processes
R Asai, T Takeuchi, K Kondo, T Niwa - International Journal of …, 2022 - Elsevier
… The spray freeze-drying (SFD) technique has been previously established to … poorly
water-soluble drugs in our laboratory. A drug nanosuspension prepared through a wet-beads milling …
water-soluble drugs in our laboratory. A drug nanosuspension prepared through a wet-beads milling …
Impact of dispersants on dissolution of itraconazole from drug-loaded, surfactant-free, spray-dried nanocomposites
M Li, I Suriel, J Vekaria, J Proske, P Orbe, M Armani… - Powder technology, 2018 - Elsevier
… been used to convert drug nanosuspensions into nanocomposite … both freeze drying and
spray drying can achieve high drug … alone, water-soluble polymers may not guarantee fast drug …
spray drying can achieve high drug … alone, water-soluble polymers may not guarantee fast drug …
[HTML][HTML] Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution from spray-dried nanocomposites
… instability, drug nanosuspensions are usually dried into … and time efficient compared to freeze
drying [32]. Hence, … as to how hydrophilic and freely water-soluble dispersants used in this …
drying [32]. Hence, … as to how hydrophilic and freely water-soluble dispersants used in this …